The Nissen-Sleeve Operation

By Elias Darido, MD, FACS
Bariatric & Weight Loss Surgeon | Houston Weight Loss Surgery Center
Published: July 2026 | Last Reviewed: July 2026

My thinking on managing GERD in bariatric patients has changed over the years, and I want to walk through why, along with what some newer published data means for one procedure I get asked about often: the Nissen-Sleeve.

Why Bypass Was the Default

For years, when an obese patient came to me with GERD, I offered gastric bypass. That was the standard answer, and in most respects it still is. Bypass diverts bile and acid away from the esophagus and has long been considered the more reliable operation for obese patients with significant reflux. Sleeve gastrectomy, by contrast, is widely described in the literature as a reflux-causing operation, and plenty of patients do develop new or worsened GERD after a standard sleeve. For a long time, that reputation was reason enough for me to steer GERD patients toward bypass instead.

Today, for most of these patients, I offer a sleeve gastrectomy with a concomitant hiatal hernia repair instead, and I’m seeing excellent reflux control. That puts me at odds with a lot of current literature and practice guidelines, so I want to explain the reasoning before getting into the newer data on hybrid procedures like the Nissen-Sleeve.

The Piece I Think Gets Missed: Not All Sleeves Are the Same

A sleeve gastrectomy is not one standardized operation performed the same way by every surgeon. The way the stomach is resected matters enormously, particularly at the incisura angularis (the junction between the horizontal and vertical parts of the stomach). An aggressively narrowed sleeve at that point distorts the stomach’s normal architecture and creates the kind of outflow resistance that raises intragastric pressure and pushes acid upward. A sleeve constructed to preserve that anatomy, rather than narrow it down aggressively, behaves very differently. In my experience, a properly resected sleeve does not carry the same reflux burden that shows up so consistently in the literature.

The Hiatal Hernia Most Bariatric Surgeons Don’t Repair

The second piece is just as important. Most obese patients have some degree of hiatal hernia, and most bariatric surgeons do not repair it at the time of sleeve gastrectomy. Leaving that hernia in place means part of the stomach sits exposed to the negative pressure environment of the chest instead of the positive pressure environment of the abdomen. That pressure gradient is a direct setup for reflux, regardless of how well the sleeve itself is constructed.

A hiatal hernia repair restores an adequate length of intra-abdominal esophagus. That segment matters because it keeps the gastroesophageal junction within positive intra-abdominal pressure, where it can act as a buffer against reflux, rather than sitting in the chest where negative pressure works against it. I now include hiatal hernia repair as a routine part of every sleeve I perform, not as an occasional add-on for patients who already have obvious symptoms.

I want to be direct about this: current guidelines and most published literature still treat sleeve gastrectomy as a reflux-inducing procedure and favor bypass for GERD patients. I’m not disputing that data as a general statement about how sleeve is typically performed and typically not paired with hernia repair. What I am saying is that a sleeve built to preserve the incisura angularis, combined with routine hiatal hernia repair, is a different operation in practice, even though it shares a name with the standard sleeve. In my patients, that combination has produced excellent reflux control, not the worsening reflux the literature would predict.

Where the Nissen-Sleeve Fits into This Question

This is exactly the backdrop against which the Nissen-Sleeve, or N-Sleeve, was developed. The N-Sleeve combines two established procedures. A Nissen fundoplication is constructed first, then the sleeve gastrectomy is performed over a bougie, resecting as much of the gastric fundus as the fundoplication allows. The goal is the same one I’ve been describing above: give patients the weight loss benefit of a sleeve while protecting them from reflux.

The original pilot study followed 25 patients operated on between 2013 and 2014, most with a hiatal hernia repaired at the same time. At one year, 22 of the 25 were free of reflux symptoms, with weight loss comparable to a standard sleeve. It was encouraging, but small and single center.

The same group has since published two larger studies. A cohort operated on between 2016 and 2018 confirmed the early findings in a bigger group. More recently, a 5-year follow-up of 144 patients reported a mean total weight loss of 22%, excess weight loss of about 59%, and GERD symptom remission in 85.5% of patients who had reflux going into surgery. Reoperation rates stayed low, around 8%, with no reported deaths. Separate randomized and comparative trials on sleeve-plus-fundoplication approaches have since reported similarly strong reflux control alongside weight loss comparable to standard sleeve.

Can The Nissen-Sleeve Play a Role in Weight Loss Management in Houston?

My own approach, a properly constructed sleeve with routine hiatal hernia repair, does not produce the acid reflux the N-Sleeve is designed to prevent. My patients already see very low rates of postoperative reflux and a very low leak rate with a standard sleeve alone. If the underlying operation isn’t causing GERD in the first place, there is nothing left for a fundoplication to fix.

This is the core reason I see no role for the N-Sleeve in how I manage overweight patients with GERD today. The N-Sleeve exists to solve a problem, post-sleeve reflux, that stems from how most surgeons construct the sleeve and whether they repair the hiatal hernia. Address those two issues directly, and the problem the N-Sleeve is built to solve doesn’t occur.

There is also a real technical cost to adding a fundoplication. It preserves part of the posterior fundus rather than resecting it, and both the newer data and my own experience suggest this can modestly blunt weight loss compared to a standard sleeve. Fundus resection lowers ghrelin secretion in a way that fundus plication does not, since plication leaves the fundic tissue, and its hormonal signaling, in place. So a patient undergoing N-Sleeve is taking on the added complexity, operative time, and complication profile of a second procedure, a fundoplication, to prevent a complication that a properly performed, hernia-repaired sleeve does not produce.

For that reason, I don’t offer the N-Sleeve as part of my current practice. A well-constructed primary sleeve with hiatal hernia repair achieves the reflux control the N-Sleeve is trying to add, without the extra surgical step.

Key Clinical Points

• Gastric bypass remains the conventional recommendation for obese patients with GERD, and much of the literature still supports that.

• Sleeve gastrectomy technique varies significantly among surgeons, particularly at the incisura angularis, and this affects reflux outcomes.

• Most bariatric surgeons do not routinely repair a hiatal hernia during sleeve gastrectomy, even though most obese patients have one.

• Hiatal hernia repair restores intra-abdominal esophageal length, which helps buffer the GE junction from reflux.

• Five-year data on the Nissen-Sleeve now shows 85.5% GERD remission with weight loss comparable to a standard sleeve.

• Dr. Darido now offers sleeve gastrectomy with routine hiatal hernia repair to most obese GERD patients, with excellent reflux control in his practice.

If you have GERD and have been told bypass is your only surgical weight loss option, I’d encourage you to come in for an evaluation at Houston Weight Loss Surgery Center. How the sleeve is constructed, and whether your hiatal hernia is addressed, matters as much as which operation you choose.

— Elias Darido, MD, FACS
Houston Weight Loss Surgery Center
Originally published: December 2016 | Last reviewed: July 2026

References

1. Amor IB, Casanova V, Vanbiervliet G, et al. The Nissen-Sleeve (N-Sleeve): Results of a Cohort Study. Obesity Surgery. 2020.

2. Nocca D, Skalli EM, Boulay E, et al. Nissen Sleeve (N-Sleeve) Operation: Preliminary Results of a Pilot Study. Surgery for Obesity and Related Diseases. 2016.

3. Yadlapati R, Gyawali CP, Pandolfino JE. AGA Clinical Practice Update on the Personalized Approach to the Evaluation and Management of GERD: Expert Review. Clinical Gastroenterology and Hepatology. 2022.

4. Tusuntuoheti Y, Maimaitiming M, Maimaitiyusufu P, et al. The Mid-Term Efficacy of Sleeve-Nissen Versus Sleeve-Toupet Fundoplication for the Management of Gastroesophageal Reflux Disease in Patients With Obesity. Obesity Surgery. 2025.

5. Maimaitiyusupu P, Aili A, Yisireyili M, et al. Comparative Efficacy of Sleeve Gastrectomy With Fundoplication Versus Standard Sleeve Gastrectomy in Obesity and Gastroesophageal Reflux Disease: A Randomised Trial. Diabetes, Obesity & Metabolism. 2025.

6. Katz PO, Dunbar KB, Schnoll-Sussman FH, et al. ACG Clinical Guideline for the Diagnosis and Management of Gastroesophageal Reflux Disease. The American Journal of Gastroenterology. 2022.